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當(dāng)前位置：首頁(yè) > 產(chǎn)品展示 > Peprotech細(xì)胞因子 > 無動(dòng)物成分的重組蛋白 > Recombinant Human M-CSF

名稱	Recombinant Human M-CSF
型號(hào)
更新時(shí)間	2023-09-24
特點(diǎn)	M-CSF是一個(gè)有效的造血因子由多種細(xì)胞包括淋巴細(xì)胞、單核細(xì)胞、成纖維細(xì)胞、內(nèi)皮細(xì)胞、成肌細(xì)胞和成骨細(xì)胞。這是一個(gè)細(xì)胞增殖的關(guān)鍵調(diào)節(jié)器,分化,和生存的血液?jiǎn)魏思?xì)胞、組織巨噬細(xì)胞。M-CSF臨床上用于治療感染,惡性腫瘤和動(dòng)脈粥樣硬化。它促進(jìn)骨髓移植后造血恢復(fù)。}

詳細(xì)內(nèi)容

一.產(chǎn)品名稱：Recombinant Human M-CSF/Peprotech M-CSF

二.Catalog Number:AF-300-25

三.Synonyms:Macrophage Colony Stimulating Factor, CSF-1, MGI-IM

四.Description:

M-CSF is a potent hematopoietic factor produced by a variety of cells including lymphocytes, monocytes, fibroblasts, endothelial cells, myoblasts and osteoblasts. It is a key regulator of cellular proliferation, differentiation, and survival of blood monocytes, tissue macrophages and their progenitor cells. M-CSF has been shown to play important roles in modulating dermal thickness, and male and female fertility. M-CSF is clinically used in the treatment of infection, malignancies and atherosclerosis. It facilitates hematopoietic recovery after bone marrow transplantation. The human is reactive in murine systems, but the murine molecule exhibits no activity on human cells. Recombinant human M-CSF is a 36.8 kDa homodimeric protein containing two 159 amino acid polypeptide subunits. Manufactured using all non-animal reagents.

五.AA Sequence:

MEEVSEYCSH MIGSGHLQSL QRLIDSQMET SCQITFEFVD QEQLKDPVCY LKKAFLLVQD IMEDTMRFRD NTPNAIAIVQ LQELSLRLKS CFTKDYEEHD KACVRTFYET PLQLLEKVKN VFNETKNLLD KDWNIFSKNC NNSFAECSSQ GHERQSEGS

六.Source:E.coli

七.Purity:Greater than 98% by SDS-PAGE gel and HPLC analyses.

八.Biological Activity:

The ED₅₀ was determined by the dose-dependent stimulation of the proliferation of murine M-NFS-60 cells is ≤ 1.0 ng/ml, corresponding to a specific activity of ≥ 1 x 10⁶ units/mg.

九.Cross Reactivity:Monkey, Mouse, Rat, Human