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名稱	Recombinant Human BMP-4
型號
更新時(shí)間	2023-09-24
特點(diǎn)	骨形成蛋白(bmp)構(gòu)成一個(gè)亞科內(nèi)TGF-β總科的結(jié)構(gòu)相關(guān)信號蛋白。這個(gè)總科的成員廣泛分布于整個(gè)身體,并參與各種生理過程在兩個(gè)前和產(chǎn)后的生活。像BMP-7 BMP-4參與骨骼和軟骨的開發(fā)和維護(hù)。BMP-4表達(dá)降低與許多骨相關(guān)疾病。}

詳細(xì)內(nèi)容

一.產(chǎn)品名稱：Recombinant Human BMP-4

二.貨號Catalog Number:AF-120-05ET

三.同義Synonyms:BMP-2B, DVR4

四.描述Description:

Bone morphogenetic proteins (BMPs) constitute a subfamily within the TGF-β superfamily of structurally related signaling proteins. Members of this superfamily are widely distributed throughout the body, and are involved in diverse physiological processes during both pre- and postnatal life. Like BMP-7, BMP-4 is involved in the development and maintenance of bone and cartilage. Reduced expression of BMP-4 is associated with a number of bone diseases, including the heritable disorder Fibrodysplasia Ossificans Progressiva. PeproTech’s E.coli-derived BMP-4 is a fully active homodimeric protein consisting of two 106 amino acid subunits, which correspond to amino acids 303-408 of the full length BMP-4 precursor. The calculated molecular weight of Recombinant Human BMP-4 (E.coli-derived) is 23.9 kDa. Manufactured using all non-animal reagents.

五.AA序列AA Sequence:

KKNKNCRRHS LYVDFSDVGW NDWIVAPPGY QAFYCHGDCP FPLADHLNST NHAIVQTLVN SVNSSIPKAC CVPSAIS MLYLDEYDKV VLKNYQEMVV EGCGCR

六.來源Source:E.coli

Purity:Greater than 98% by SDS-PAGE gel and HPLC analyses.

七.生物活性Biological Activity:

Determined by its ability to induce alkaline phosphatase production by ATDC-5 cells. The expected ED₅₀ for this effect is 5-10 ng/ml.

八.交叉性Cross Reactivity:Mouse, Human, Rat